abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:Pathological changes induced by cadmium aerosol had features common to the changes evoked by oxidants. Female rats were exposed to fumes of lead, antimony, zinc and cadmium (15-100 nmoles/m3). One hour after termination of exposure, superoxide dismutase (SOD) activity in erythrocytes of the exposed rats lowered by 15-...

journal_title：Archives of toxicology

authors： Minami M,Koshi K,Homma K,Suzuki Y

更新日期：1982-03-01 00:00:00

abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...

journal_title：Archives of toxicology

authors： Rauws AG,Olling M,Timmerman A

更新日期：1982-03-01 00:00:00

abstract：:Dose-dependent excretion of p,p'DDE in rats was investigated. p,p'DDE itself was the major excreta in rats. But some o,p'isomer of DDE was detected in feces by GC-MS analysis. The excretion of p,p'DDE after a single administration was modified by its dose level. The time pattern of p,p'DDE excretion agrees well with t...

journal_title：Archives of toxicology

authors： Ando M

更新日期：1982-01-01 00:00:00

abstract：:Cats were given vincristine sulfate (50 micrograms/kg i.v. every 4 days) and studied after 7-29 injections when neurological deficits became evident. The conduction velocity spectrum of individual afferent nerves from soleus muscles was shifted toward slower velocities. Relatively few functional muscle spindles or oth...

journal_title：Archives of toxicology

authors： Goldstein BD,Lowndes HE,Cho E

更新日期：1981-11-01 00:00:00

abstract：:Groups of rats were exposed simultaneously to manganese chloride (3 mg Mn2+/ml water) through drinking water and lead acetate intraperitoneally at dosages of 5.0, 8.0 and 12.0 mgPb2+/kg daily for a period of 14 days. The magnitude of changes in the behavioral pattern, contents of biogenic amines and accumulation of le...

journal_title：Archives of toxicology

authors： Chandra AV,Ali MM,Saxena DK,Murthy RC

更新日期：1981-11-01 00:00:00

abstract：:The possibility that the exposure of the embryo to certain chemical substances can lead to behavioral disturbances is known from human epidemiological studies, e.g., in chronic poisoning with mercury and ethanol. Therefore, efforts are made to develop toxicological techniques with which new behavioral teratogens can b...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1981-09-01 00:00:00

abstract：:Regarding the potential impact of traffic-born air pollutants on public health, in recent years attention has increasingly been focused on the possible effects on the cardiovascular system. In order to investigate this problem further, the influence of long-term exhaust gas exposure on rats has been studied. One hundr...

journal_title：Archives of toxicology

authors： Roggendorf W,Neumann H,Thron HL,Schneider H,Sarasa-Corral JL

更新日期：1981-07-01 00:00:00

abstract：:A single dose of 10 mg methylmercury chloride per kg body weight was given to 30 days old rats and to adult rats (180-200g)(. This resulted in brain levels of 1.4-2.2 micrograms Hg/g wet weight. In the young rats electron microscopic morphometry showed swelling of the granule cells. The extent of changes was more pron...

journal_title：Archives of toxicology

authors： Syversen TL,Totland G,Flood PR

更新日期：1981-04-01 00:00:00

abstract：:A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method all...

journal_title：Archives of toxicology

authors： van Doorn R,Delbressine LP,Leijdekkers CM,Vertin PG,Henderson PT

更新日期：1981-03-01 00:00:00

abstract：:Between 0.25-25 micrograms of an aqueous solution of either mercuric chloride or methyl mercuric acetate was injected directly into the sciatic nerve of 28 adult Wistar rats. The resultant pathological changes in the nerve were examined by teasing individual fibres and by light and electron microscopy. In most respect...

journal_title：Archives of toxicology

authors： Mitchell J,Gallagher PJ

更新日期：1980-12-01 00:00:00

abstract：:DNA damage induced by methylmethane sulfonate, cyclophosphamide, doxorubicin and procarbazine in male germ cells was assessed in rabbits by the demonstration of unscheduled DNA synthesis (UDS), in meiotic and postmeiotic phases of maturation. Immediately after treatment by the intravenous route tritiated thymidine was...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1980-11-01 00:00:00

abstract：:In mutagenicity testing of pharmaceuticals it is advisable, whenever possible, to use in vivo mammalian systems where the pharmacokinetic properties of a drug would be more or less similar to those in man. However, although there are a number of different genetic endpoints which are important in mutagen testing, suffi...

journal_title：Archives of toxicology

authors： Matter BE,Tsuchimoto T

更新日期：1980-11-01 00:00:00

abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...

journal_title：Archives of toxicology

authors： Lotti M,Johnson MK

更新日期：1980-10-01 00:00:00

abstract：:The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin-induced histopathologic changes in renal tissue were examine in rats. Gentamicin (30, 60, 120, 160 mg/kg) was administered s.c. for 10 consecutive days with or without isosorbide pretreatment. Osmotic diuresis with ...

journal_title：Archives of toxicology

authors： Newman RA,Weinstock LB,Gump DW,Hacker MP,Yates JW

更新日期：1980-09-01 00:00:00

abstract：:Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma ...

journal_title：Archives of toxicology

authors： Hampel G,Crome P,Widdop B,Goulding R

更新日期：1980-07-01 00:00:00

abstract：:pp'DDT (600 mg/kg, orally) produced an increase in the level of free ammonia and a decrease of acetylcholine in the corpus striatum of rats. These effects were maximal 5 h after the administration of pp'DDT. The animals showed tremors after 2 h, mild or moderate convulsions after 3.5 h and severe convulsions 5 h after...

journal_title：Archives of toxicology

authors： Matin MA,Jaffery FN,Kar PP

更新日期：1980-05-01 00:00:00

abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...

journal_title：Archives of toxicology

authors： Höke H,Krell H,Pfaff E

更新日期：1980-03-01 00:00:00

abstract：:Clinical and electrophysiological examinations were performed on 12 patients with toxic neuropathy following accidental ingestion of alcohol polluted by triorthocresyl phosphate (TOCP). Concurrent PNS and CNS lesions were found in all patients. Two to three months after ingestion, five of them showed prevalent signs o...

journal_title：Archives of toxicology

authors： Vasilescu C,Florescu A

更新日期：1980-02-01 00:00:00

abstract：:Sotalol [4-(2-isopropylamino-1-hydroxyethyl)-methane-sulfonanilide hydrochloride] is a beta-adrenergic blocking agent. Despite the widespread use of these drugs, poisonings are not frequent. In this report the authors describe the first recorded case of fatal sotalol overdosage to their knowledge. The results of toxic...

journal_title：Archives of toxicology

authors： Montagna M,Groppi A

更新日期：1980-01-01 00:00:00

abstract：:The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of t...

journal_title：Archives of toxicology

authors： Nakanishi S,Shiohara E,Tsukada M,Yamazaki H,Nishiguchi K,Saladin R

更新日期：1979-12-01 00:00:00

abstract：:Intravenous administration of lead acetate to rabbits for 10 weeks at 2 week intervals resulted in significantly elevated blood lead levels, slight anemia with marked microspherocytosis and moderate basophilic stippling, and marked depression of red cell delta-aminolevulinic acid (ALA) dehydratase activity. However th...

journal_title：Archives of toxicology

authors： Fujii H

更新日期：1979-10-01 00:00:00

abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1979-10-01 00:00:00

abstract：:The excretion and biotransformation of [14C] 1,1-dichloroethylene (vinylidene chloride, VDC) after administration of a single oral dose has been investigated in female rats. Seventy-two hours after a dose of 0.5, 5.0, and 50.0 mg/kg, 1.26, 9.70, 16.47%, respectively, are exhaled as unchanged VDC, and 13.64, 11.35, 6.1...

journal_title：Archives of toxicology

authors： Reichert D,Werner HW,Metzler M,Henschler D

更新日期：1979-07-11 00:00:00

abstract：:Nine bispyridinium oximes containing two pyridinium rings linked by dimethylether were synthesised. Each compound had on one of the pyridinium rings a hydroxyiminomethyl group in position 2 or 4, while the other ring was unsubstituted or had a methyl or a hydroxyiminomethyl group in position 2 or 4. The reactivating p...

journal_title：Archives of toxicology

authors： Simeon V,Wilhelm K,Granov A,Besarović-Lazarev S,Buntić A,Fajdetić A,Binenfeld Z

更新日期：1979-02-23 00:00:00

abstract：:Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly although the perirenal xylene concentration increased in both test groups between the first and second week o...

journal_title：Archives of toxicology

authors： Savolainen H,Vainio H,Helojoki M,Elovaara E

更新日期：1978-12-28 00:00:00

abstract：:Chemical formation of dichlorvos (2, 2-dichlorovinyl dimethyl phosphate) was found to occur in mouse brain after i.p. injection of metrifonate (2, 2, 2-trichloro-1-hydroxyethyl dimethyl phosphonate). A mass fragmentographic technique was used. Different isotopic variants were used both as internal standards and to com...

journal_title：Archives of toxicology

authors： Nordgren I,Bergström M,Holmstedt B,Sandoz M

更新日期：1978-10-13 00:00:00

abstract：:The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbit...

journal_title：Archives of toxicology

authors： Schnell RC,Yuhas EM,Pence DH,Means JR,Roberts SA,Yau ET,Miya TS,Mennear JH

更新日期：1978-08-09 00:00:00

abstract：:Pregnant mice administered per os during the days 1--3 (plug day = day 0) post conception (p.c.) with 375 mg 2,2'-dichlorobiphenyl/kilograms/day revealed on day 18 p.c. increased number of resorptions and doses up from 500 milligrams/kilograms/day led to a substantial retardation of the prenatal development. Based on ...

journal_title：Archives of toxicology

authors： Török P

更新日期：1978-08-09 00:00:00

abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...

journal_title：Archives of toxicology

authors： Vohland HW,Schirop T,Barckow D,Kreutz G,Streichert B

更新日期：1978-06-16 00:00:00

abstract：:Bromethylbutyramide (Carbromide), a quantitatively important metabolite of carbromal, diminished the contractility of electrically driven and the frequency of spontaneously beating guinea-pig atria. The negative inotropic action of bromethylbutyramide occurred at concentrations which are reached in human carbromal poi...

journal_title：Archives of toxicology

authors： Strubelt O

更新日期：1978-04-27 00:00:00

abstract：:To investigate the effect of long term hashish use on T-lymphocytes we have measured the incorporation of 14C-thymidine by peripheral blood lymphocytes, unstimulated and stimulated by phytohemagglutinin, as well as the proportion and number of E-rosettes in 12 healthy male chronic users of the drug before and after a ...

journal_title：Archives of toxicology

authors： Kaklamani E,Trichopoulos D,Koutselinis A,Drouga M,Karalis D

更新日期：1978-04-27 00:00:00

abstract：:A rapid gas-chromatographic method for the qualitative and quantitative measurement of various drugs in human plasma and other body fluids has been developed. The extraction procedure is done within 5 min, and gas-chromatographic measurement carried out on 2 diverse columns with detection by flame ionisation detectors...

journal_title：Archives of toxicology

authors： Pentz R,Schütt A

更新日期：1978-01-25 00:00:00

abstract：:When rats were dosed with 14 microgram/kg 3H-isoproterenol, 3H-radioactivity was measurable in the liver until 48 h. This amount was not different in livers of animals which have been pretreated with diethyl maleate. After exhaustive extraction, a significant amount of 3H-radioactivity from isoproterenol could be dete...

journal_title：Archives of toxicology

authors： Remmer H,Scheulen M,Kappus H,Bolt HM

更新日期：1977-12-30 00:00:00

abstract：:The uptake, distribution, and elimination of 3H-toluene in various tissues of rats were studied after inhalation or after gastric intubation. The maximum radioactivity was measured 2--3 h after gastric intubation in tissues, except in white adipose tissue, where the peak radioactivity was reached at 5 h. After inhala...

journal_title：Archives of toxicology

authors： Pyykkö K,Tähti H,Vapaatalo H

更新日期：1977-09-28 00:00:00

abstract：:The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M.K. Biochem. J. 114, 711-717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selec...

journal_title：Archives of toxicology

authors： Johnson MK

更新日期：1977-06-18 00:00:00

abstract：:During aerobic incubation of trichloroethylene with rabbit liver microsomes and NADPH a difference absorption peak appears at 451-452 nm. Trichloroethylene does not form a ligand absorption spectrum with hepatic microsomes reduced by dithionite, or in anaerobic incubates in the presence of NADPH. Addition of trichloro...

journal_title：Archives of toxicology

authors： Uehleke H,Tabarelli-Poplawski S,Bonse G,Henschler D

更新日期：1977-06-18 00:00:00

abstract：:Forty-eight hours after a single dose of 14C-imipramine to rats, 14C-radioactivity could be measured in the following organs: liver greater than kidney greater than serum greater than fat greater than spleen greater than duodenum greater than lung greater than muscle and brain. Liver microsomes contained the main part...

journal_title：Archives of toxicology

authors： Kappus H

更新日期：1976-12-23 00:00:00

abstract：:The cadmilm-induced (Cd) damage of mammalian testes is thought to be correlated with an inhibition of carbonic anhydrase (CAH) by Cd. Since Cd causes dose-dependent changes in blood flow of the testes, an inhibition of CAH in the testes could be simulated by a decrease of CAH-rich erythrocytes. Therefore, CAH activiti...

journal_title：Archives of toxicology

authors： Alsen C,Köpcke C,Ohnesorge FK,Schneider J

更新日期：1976-12-23 00:00:00

abstract：:The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase (low values, during light, rising in the evening with maximum at 12.00 p.m.) are investigated in rats under diverse conditions. Intragastral administration of cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both e...

journal_title：Archives of toxicology

authors： Mayer D

更新日期：1976-12-17 00:00:00